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1

Properties and applications of starch-converting enzymes of the α-amylase family

Marc J.E.C van der Maarel, Bart van der Veen, Joost C.M Uitdehaag, Hans Leemhuis, L Dijkhuizen

Journal:

Journal of Biotechnology

Year:

2002

Language:

english

File:

PDF, 467 KB

english, 2002

2

The seven types of drug discovery waste: toward a new lean for the drug industry

Joost C.M. Uitdehaag

Journal:

Drug Discovery Today

Year:

2011

Language:

english

File:

PDF, 93 KB

english, 2011

3

Internet-based self-help treatment for depression in multiple sclerosis: study protocol of a randomized controlled trial

Rosa E Boeschoten, Joost Dekker, Bernard MJ Uitdehaag, Chris H Polman…

Journal:

Year:

2012

Language:

english

File:

PDF, 291 KB

english, 2012

4

The three transglycosylation reactions catalyzed by cyclodextrin glycosyltransferase from Bacillus circulans (strain 251) proceed via different kinetic mechanisms

Bart A. van der Veen, Gert-Jan W. M. van Alebeek, Joost C. M. Uitdehaag, Bauke W. Dijkstra, Lubbert Dijkhuizen

Journal:

Year:

2000

Language:

english

File:

PDF, 770 KB

english, 2000

5

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

Joost CM Uitdehaag, Folkert Verkaar, Husam Alwan, Jos de Man, Rogier C Buijsman, Guido JR Zaman

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.60 MB

english, 2012

6

Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase α-cyclodextrin production

Bart A van der Veen, Joost C.M Uitdehaag, Dirk Penninga, Gert-Jan W.M van Alebeek, Loraine M Smith, Bauke W Dijkstra, Lubbert Dijkhuizen

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 990 KB

english, 2000

7

Structures of Maltohexaose and Maltoheptaose Bound at the Donor Sites of Cyclodextrin Glycosyltransferase Give Insight into the Mechanisms of Transglycosylation Activity and Cyclodextrin Size Specificity †,‡

Uitdehaag, Joost C. M., van Alebeek, Gert-Jan W. M., van der Veen, Bart A., Dijkhuizen, Lubbert, Dijkstra, Bauke W.

Journal:

Year:

2000

Language:

english

File:

PDF, 255 KB

english, 2000

8

[Progress in Biotechnology] Stability and Stabilization of Biocatalysts, Proceedings of an International Symposium organized under auspices of the Working Party on Applied Biocatalysis of the European Federation of Biotechnology, the University of Cordoba, Spain, and the Spanish Society of Biotechnology Volume 15 || A strategy for engineering thermostability: the case of cyclodextrin glycosyltransferase

Uitdehaag, Joost C.M.

Year:

1998

Language:

english

File:

PDF, 406 KB

english, 1998

9

Catalytic mechanism and product specificity of cyclodextrin glycosyltransferase, a prototypical transglycosylase from the α-amylase family

Joost C.M Uitdehaag, Bart A van der Veen, Lubbert Dijkhuizen, Bauke W Dijkstra

Journal:

Enzyme and Microbial Technology

Year:

2002

Language:

english

File:

PDF, 468 KB

english, 2002

10

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

Michels, Helen, Seinstra, Renée I., Uitdehaag, Joost C. M., Koopman, Mandy, van Faassen, Martijn, Martineau, Céline N., Kema, Ido P., Buijsman, Rogier, Nollen, Ellen A. A.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.06 MB

english, 2016

11

The dependency game: Multiperson reciprocal sharing leads to stable cooperation which can evolve into group formation

Joost C.M. Uitdehaag

Journal:

Journal of Theoretical Biology

Year:

2009

Language:

english

File:

PDF, 474 KB

english, 2009

12

Enzymatic circularization of a malto-octaose linear chain studied by stochastic reaction path calculations on cyclodextrin glycosyltransferase

Joost C.M. Uitdehaag, Bart A. van der Veen, Lubbert Dijkhuizen, Ron Elber, Bauke W. Dijkstra

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2001

Language:

english

File:

PDF, 407 KB

english, 2001

13

Life in a monastic lab

Uitdehaag, Joost

Journal:

Year:

2009

Language:

english

File:

PDF, 526 KB

english, 2009

14

Target residence time-guided optimization on TTK kinase results in inhibitors with potent anti-proliferative activity

Uitdehaag, Joost C.M., de Man, Jos, Willemsen-Seegers, Nicole, Prinsen, Martine B.W., Libouban, Marion A.A., Sterrenburg, Jan Gerard, de Wit, Joeri J.P., de Vetter, Judith R.F., de Roos, Jeroen A.D.M.

Journal:

Journal of Molecular Biology

Year:

2017

Language:

english

File:

PDF, 1.93 MB

english, 2017

15

Comparison of the Cancer Gene Targeting and Biochemical Selectivities of All Targeted Kinase Inhibitors Approved for Clinical Use

Uitdehaag, Joost C. M., de Roos, Jeroen A. D. M., van Doornmalen, Antoon M., Prinsen, Martine B. W., de Man, Jos, Tanizawa, Yoshinori, Kawase, Yusuke, Yoshino, Kohichiro, Buijsman, Rogier C., Zaman, G

Journal:

Year:

2014

Language:

english

File:

PDF, 4.89 MB

english, 2014

16

Where is the optimism? Warrior teachings to regain the drug discovery spirit

Joost C.M. Uitdehaag

Journal:

Drug Discovery Today

Year:

2007

Language:

english

File:

PDF, 99 KB

english, 2007

17

Reassessment of Acarbose as a Transition State Analogue Inhibitor of Cyclodextrin Glycosyltransferase †

Mosi, Renee, Sham, Howard, Uitdehaag, Joost C. M., Ruiterkamp, Richard, Dijkstra, Bauke W., Withers, Stephen G.

Journal:

Year:

1998

Language:

english

File:

PDF, 106 KB

english, 1998

18

Feasibility and outcome of a web-based self-help intervention for depressive symptoms in patients with multiple sclerosis: A pilot study

Rosa E. Boeschoten, Magdalena M. Nieuwenhuis, Patricia van Oppen, Bernard M.J. Uitdehaag, Chris H. Polman, Emma H. Collette, Pim Cuijpers, Aartjan T.F. Beekman, Joost Dekker

Journal:

Journal of the Neurological Sciences

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

19

Engineering of cyclodextrin glycosyltransferase reaction and product specificity

Bart A van der Veen, Joost C.M Uitdehaag, Bauke W Dijkstra, Lubbert Dijkhuizen

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

2000

Language:

english

File:

PDF, 947 KB

english, 2000

20

General Model for Lipid-Mediated Two-Dimensional Array Formation of Membrane Proteins: Application to Bacteriorhodopsin

Sabra, Mads C., Uitdehaag, Joost C.M., Watts, Anthony

Journal:

Biophysical Journal

Year:

1998

Language:

english

File:

PDF, 1.54 MB

english, 1998

21

Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158

Grobben, Yvonne, Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Tabak, Werner W.A., Man, Jos de, Buijsman, Rogier C., Zaman, Guido J.R.

Journal:

Journal of Structural Biology: X

Year:

2019

File:

PDF, 1.89 MB

2019

22

Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis

Boeschoten, Rosa E., Braamse, Annemarie M.J., Beekman, Aartjan T.F., Cuijpers, Pim, van Oppen, Patricia, Dekker, Joost, Uitdehaag, Bernard M.J.

Journal:

Journal of the Neurological Sciences

Year:

2017

Language:

english

File:

PDF, 1.07 MB

english, 2017

23

The role of arginine 47 in the cyclization and coupling reactions of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 : Implications for product inhibition and product specificity

Bart A. van der Veen, Joost C. M. Uitdehaag, Bauke W. Dijkstra, Lubbert Dijkhuizen

Journal:

Year:

2000

Language:

english

File:

PDF, 759 KB

english, 2000

24

Differentiation of Multiple Sclerosis from Other Inflammatory Disorders and Cerebrovascular Disease: Value of Spinal MR Imaging1

Bot, Joost C. J., Barkhof, Frederik, à Nijeholt, Geert Lycklama, van Schaardenburg, Dirkjan, Voskuyl, Alexandre E., Ader, Herman J., Pijnenburg, Jolanda A. L., Polman, Chris H., Uitdehaag, Bernard M.

Journal:

Year:

2002

Language:

english

File:

PDF, 833 KB

english, 2002

25

TTK inhibitors as a targeted therapy for CTNNB1 (β-catenin) mutant cancers

Zaman, Guido J.R., de Roos, Jeroen A.D.M., Libouban, Marion A.A., Prinsen, Martine B.W., de Man, Jos, Buijsman, Rogier C., Uitdehaag, Joost C.M.

Journal:

Molecular Cancer Therapeutics

Year:

2017

Language:

english

File:

PDF, 7.33 MB

english, 2017

26

Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance

Willemsen-Seegers, Nicole, Uitdehaag, Joost C.M., Prinsen, Martine B.W., de Vetter, Judith R.F., de Man, Jos, Sawa, Masaaki, Kawase, Yusuke, Buijsman, Rogier C., Zaman, Guido J.R.

Journal:

Journal of Molecular Biology

Year:

2017

Language:

english

File:

PDF, 965 KB

english, 2017

27

Bet hedging based cooperation can limit kin selection and form a basis for mutualism

Joost C.M. Uitdehaag

Journal:

Journal of Theoretical Biology

Year:

2011

Language:

english

File:

PDF, 688 KB

english, 2011

28

Managing freedom: Managing researchers as if they were warriors

Joost Uitdehaag

Journal:

Drug Discovery Today

Year:

2008

Language:

english

File:

PDF, 1.40 MB

english, 2008

29

X-Ray Structures of the LXRα LBD in Its Homodimeric Form and Implications for Heterodimer Signaling

Xavier Fradera, Diep Vu, Olaf Nimz, Robert Skene, David Hosfield, Robert Wynands, Andrew J. Cooke, Anders Haunsø, Angela King, D. Jonathan Bennett, Ross McGuire, Joost C.M. Uitdehaag

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 2.28 MB

english, 2010

30

Trapping and Characterization of the Reaction Intermediate in Cyclodextrin Glycosyltransferase by Use of Activated Substrates and a Mutant Enzyme †

Mosi, Renee, He, Shouming, Uitdehaag, Joost, Dijkstra, Bauke W., Withers, Stephen G.

Journal:

Year:

1997

Language:

english

File:

PDF, 307 KB

english, 1997

31

Combined cellular and biochemical profiling to identify predictive drug response biomarkers for kinase inhibitors approved for clinical use between 2013 and 2017

Uitdehaag, Joost C.M., Kooijman, Jeffrey J., de Roos, Jeroen A.D.M., Prinsen, Martine B.W., Dylus, Jelle, Willemsen-Seegers, Nicole, Kawase, Yusuke, Sawa, Masaaki, de Man, Jos, van Gerwen, Suzanne J.C

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 16.99 MB

english, 2018

32

A theoretical entropy score as a single value to express inhibitor selectivity

Joost CM Uitdehaag, Guido JR Zaman

Journal:

BMC Bioinformatics

Year:

2011

Language:

english

File:

PDF, 1.09 MB

english, 2011

33

10.1038/8235

Uitdehaag, Joost C. M., Mosi, Renée, Kalk, Kor H., van der Veen, Bart A., Dijkhuizen, Lubbert, Withers, Stephen G., Dijkstra, Bauke W.

Journal:

Natural Structural Biology

Year:

1999

Language:

english

File:

PDF, 299 KB

english, 1999

34

Identification of Acceptor Substrate Binding Subsites +2 and +3 in the Amylomaltase from Thermus thermophilus HB8 †

Kaper, Thijs, Leemhuis, Hans, Uitdehaag, Joost C. M., van der Veen, Bart A., Dijkstra, Bauke W., van der Maarel, Marc J. E. C., Dijkhuizen, Lubbert

Journal:

Year:

2007

Language:

english

File:

PDF, 160 KB

english, 2007

35

Does the presence of multiple sclerosis impact on symptom profile in depressed patients?

Boeschoten, Rosa E., Schaakxs, Roxanne, Dekker, Joost, Uitdehaag, Bernard M.J., Beekman, Aartjan T.F., Smit, Johannes H., Penninx, Brenda W.J.H., van Oppen, Patricia

Journal:

Journal of Psychosomatic Research

Year:

2017

Language:

english

File:

PDF, 534 KB

english, 2017

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